Introduction Guanidines is a key structural element of many biological active compounds such as arginine (A small group of about amino acids commonly found in protein) 1 It is a basic unit found in the compound which is used for the treatment of many disease such as cancer, diabetic 2, metabolic process, guanidine itself is a strong base (pka of conjugated acid is 125) 4 It wasThe guanidine group is far more basic than an amine, and the positive charge should be much more stable over a wide pH range The targetbinding affinity of oligonucleotides with GuNA was compared with that of LNA Docking studies were carried out by the authors and they indicated that norfloxacin and 2 recognize the same binding site of the NorA efflux pump, and thus the inhibition of the pump may be due to a competitive mechanism Interestingly, the guanidine group of 2 is projected in the NLobe of NorA efflux pump allowing an Hbond with residue G101This interaction seems to be
Autocatalytic And Oscillatory Reaction Networks That Form Guanidines And Products Of Their Cyclization Nature Communications
